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KMID : 0880220190570030185
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Journal of Microbiology
2019 Volume.57 No. 3 p.185 ~ p.194
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Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system
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Jo In-Seong
Kim Jin-Sik
Xu Yongbin
Hyun Jae-Kyung
Lee Kang-Seok
Ha Nam-Chul
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Abstract
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Tripartite efflux pumps and the type I secretion system of Gram-negative bacteria are large protein complexes that span the entire cell envelope. These complexes expel antibiotics and other toxic substances or transport protein toxins from bacterial cells. Elucidating the binary and ternary complex structures at an atomic resolution are crucial to understanding the assembly and working mechanism. Recent advances in cryoelectron microscopy along with the construction of chimeric proteins drastically shifted the assembly models. In this review, we describe the current assembly models from a historical perspective and emphasize the common assembly mechanism for the assembly of diverse tripartite pumps and type I secretion systems.
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KEYWORD
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multidrug resistance, multidrug efflux pump, structure, cryo-electron microscopy
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